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GK QUESTION#3593

Which essential micronutrient plays a clear role in the synthesis, storage and secretion of insulin in the hexameric form as well as in the conformational integrity of insulin?

  1. AZincCorrect answer
  2. BFluoride
  3. CSelenium
  4. DPhosphorus
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Answer

A. Zinc

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Explanation

Zinc ions coordinate insulin molecules in storage hexamers in pancreatic beta-cell secretory granules. The hexamers dissociate after secretion; the active circulating hormone is principally monomeric. The question’s hexamer clue identifies zinc among the choices.

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